Ligand Binding to A1Adenosine Receptors is Influenced by Protonation
- 1 July 1991
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (5) , 1139-1140
- https://doi.org/10.1080/07328319108047255
Abstract
Studies on the pH dependence of ligand binding to A1 adenosine receptors revealed that protonation of a histidine residue in the binding pocket is accompanied by high affinity agonist binding.Keywords
This publication has 2 references indexed in Scilit:
- Propylbenzilylcholine Mustard Labels an Acidic Residue in Transmembrane Helix 3 of the Muscarinic ReceptorJournal of Biological Chemistry, 1989
- Chemical modification of A1 adenosine receptors in rat brain membranes. Evidence for histidine in different domains of the ligand binding site.Journal of Biological Chemistry, 1988