DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection
- 1 April 1995
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 69 (4) , 2684-2688
- https://doi.org/10.1128/jvi.69.4.2684-2688.1995
Abstract
DNA vaccination has been evaluated with the lymphocytic choriomeningitis virus (LCMV) model system. Plasmid DNA encoding the LCMV nucleoprotein, when injected intramuscularly, induces both antiviral antibodies and cytotoxic T lymphocytes. Injection of DNA encoding the nucleoprotein or the viral glycoprotein confers protection against normally lethal LCMV challenge in a major histocompatibility complex dependent manner. The protection conferred is incomplete, but it is most probably mediated by the induced cytotoxic T lymphocytes.Keywords
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