Comparison of Gas Clearance and Radioactive Microspheres for Pancreatic Blood Flow Measurement

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Abstract
Measurement of pancreatic blood flow (BPF) is technically demanding. Although radiolabeled microspheres are considered the "gold standard" for PBF assessment, they have practical limitations. In the current study, H2 and xenon-133 gas clearance techniques were adapted to PBF measurement and compared to radiolabeled microscope techniques. Simultaneous measurements of PBF were made using either hydrogen or xenon gas washout and radiolabeled microspheres. Measurements were made under basal, vasoconstricted (vasopressin 2U i.v or nicotine 4 .mu.g/kg/h) and stimulated (secretin 125 ng/kg/h or 2 U/kg i.v.) conditions (random order). Mean PBF was 26.9 .+-. 5.3, 50.5 .+-. 2.3, and 27.6 .+-. 5.2 ml/min/100 g basally, 36.9 .+-. 8.0, 90.1 .+-. 18.9, and 81.7 .+-. 14.5 ml/min/100 g in the vasocontricted state of hydrogen gas clearance, xenon gas clearance, and radiolabeled microspheres, respectively. The H2 clearance technique resulted in tissue trauma, was complicated by frequent electrode displacement, and correlated poorly (r2 = 0.36, p < 0.05) with microscopes data. We conclude that xenon clearance offers an attractive, validated alternative to radiolabeled microspheres for measuring pancreatic blood flow.

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