Keratosis Senilis: A Biologic Concept of its Pathogenesis and Diagnosis Based on the Study of Normal Epidermis and 1730 Seborrheic and Senile Keratoses

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Abstract
This paper deals with a histogenetic interpretation of keratosis senilis, which defines the condition as a distrubance in the normal symbiosis of malpighian cells and adnexal epithelium in the epidermis. The disturbed balance is believed to be the result of individual epidermal cells undergoing heritable changes that (1) make the cells functionally inadequate, but at the same time, (2) increase the proliferative tendencies of the cells, and (3) through progression, lead to the development of carcinoma in situ and, frequently, to invasive carcinoma. The practical significance of this intrepretation is discussed as it relates to the histologic diagnosis of keratosis senilis.

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