Toxicity of Some Synthetic Pteridines in Rats.

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Abstract
The toxicities of five 4-amino-pteridine compounds were studied in rats. The 2-thiol-substituted pteridines were not found to be toxic in the doses used. The 2,4-diamino-6,7-dihydroxy-pteridine and 2,4-diamino-pteridine interfered with the growth rate. The latter compound caused crystalline deposits in the renal tubules, and the extent of the deposits correlated well with the effects upon body wt. No histological effects were noted in the liver and bone marrow, and none of the compounds altered the blood picture.
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