Developmental Studies on Gamma-Glutamyl Transferase in Rat Intestinal Mucosa

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Abstract
The activity of γ-GT in rat intestinal mucosa has been studied during normal development. No significant differences in enzymatic activity have been recorded between 21-day-old fetuses, neonates tested at 3, 10, 20 and 30 days and older animals (65 days). Only in the period immediately prior to birth did the liver γ-GT display activity levels similar to those of intestinal γ-GT. In neonates and in adult rats, the intestinal γ-GT activity was much higher as compared to the enzymatic activity in the liver, possibly revealing a species feature in rats. The results of the studies show that the rat is particularly suitable for experimental studies on intestinal γ-GT in pathological conditions.

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