MODULATING EFFECT BY ZINC ON HEPATIC LYSOSOMAL FRAGILITY INDUCED BY SURFACE-ACTIVE AGENTS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 27  (3) , 587-598
Abstract
In vitro studies on rat hepatic lysosomal stability, as assessed by release of .beta.-glucuronidase, were performed to show the comparative influence of surface-active agents which act by various mechanisms. Bile acids, short chain alcohols, acetylsalicylic acid and Triton X-100 were studied and their interaction with Zn. The detergents and alcohols enhanced release of the acid hydrolase in a dose dependent fashion, but acetylsalicylic acid did not. Zn antagonized the effects in a non-specific manner. Zn may stabilize lysosomes by direct action on the lysosomal membrane, such as by surface protein interactions, but the precise mechanism remains unknown.