Different effects of 4‐aminopyridine on sensory and motor fibers
- 1 January 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 36 (1) , 117
- https://doi.org/10.1212/wnl.36.1.117
Abstract
Mammalian motor and sensory fibers respond differently to the potassium channel-blocking agent, 4-aminopyridine (4-AP). The action potentials of the motor fibers increase in duration after 4-AP, while the sensory fibers respond with bursts of action potentials after a single stimulus. These differences may account for the paresthesias reported by patients with multiple sclerosis following treatment with 4-AP.This publication has 11 references indexed in Scilit:
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