Prostaglandins as Mediators of Vasotonia in the Immature Retina

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Abstract
In vivo observations of the immature beagle puppy retina indicates that in general O2-breathing induces vasoconstruction whereas CO2 or CO2 combined with O2 induces vasodilation. Whether a specific correlation could be found between this pattern of vascular response to changes in blood gas content and production of prostaglandins in the eye was studied. Prostaglandin production by puppy choroidal and retinal tissues and platelets exposed in vitro to these gas combinations was such that it appears platelet-derived thromboxane could have a significant influence in determining retinal vasotonia.