Relationship of maximal tubular phosphate reabsorption to dietary phosphate in the dog

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Abstract
In normal dogs, the maximal tubular reabsorption of phosphate (Tmp) on moderate phosphate (P) intake has been compared to that on high P intake. Oral P loading caused a reduction in glomerular filtration rate (GFR) in all the animals. A significant reduction in Tmp could be demonstrated in five of the six dogs while on sustained oral P loading. This decline in Tmp was significantly greater than could be accounted for by the regression of Tmp on GFR. A return toward normal values for TmP occurred following resumption of a normal diet. The reduction in Tmp during oral P loading suggests that a reduction in renal tubular reabsorption of phosphate (TRP) is one means whereby excess phosphate is eliminated from the body. This reduction in TRP may be related to an increased release of endogenous parathyroid hormone.

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