Effect of Intermittent Exposure to Simulated High Altitude in Erythropoiesis in the Guinea Pig.

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Abstract
Groups of guinea pigs were exposed to simulated altitudes of 23,000 and 30,000 ft. 6 hrs. a day, 6 days/wk. The degree of acclimatization obtained in the animals was detd. by increase in Hb, erythrocytes, and hematocrit values. Mean control values were: Hb 14.4 g/100 ml, erythrocytes 5.07 million, and hematocrit 43%. After exposure to either altitude for 100 hrs. the animals were about one-half acclimatized, the avg. blood values being: Hb 19.0 g/100 ml, erythrocytes 6.5 million, and hematocrit 60%. After 200 hrs.'' exposure to either altitude they were fully acclimatized, the avg. blood values being: Hb 24.0 g/100 ml, erythrocytes 8.3 million, and hematocrit 76%. Longer terms of exposure resulted in no significant increase in these 3 factors. Several individual animals showed almost 100% increases over the mean control values. Reticulocytosis and enlargement of the spleen were found in most of the animals.

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