6-CHLORO-2-(1-PIPERAZINYL) QUINOXALINE (CPQ) - ACTION ON SEROTONIN-INDUCED BEHAVIORAL-RESPONSES AND INTERACTIONS WITH CHLOROMETHAMPHETAMINE AND DIMETHYL-META-TYRAMINE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 235  (1) , 103-115
Abstract
CPQ was examined pharmacologically and biochemically as an inhibitor of the neuronal reuptake of serotonin, dopamine and norepinephrine. The compound was 25-50 times more potent than chlorimipramine in potentiating the head-twitch response to 5-hydroxytryptophan (5-HTP) and in antagonizing p-chloromethamphetamine (PCMA)-induced depletion of brain serotonin in rats. CPQ also potentiated the forepaw clonus produced by 5-HTP in rats and antagonized PCMA-induced head twitches. At dose levels 30 times those necessary to significantly affect serotoninergic systems, CPQ was ineffective in antagonizing either tetrabenazine-induced sedation in mice or the depletion of rat brain and heart norepinephrine or brain dopamine produced by 4, .alpha.-dimethyl meta-tyramine (H77/77). The data indicate that CPQ exhibits a high degree of potency and selectivity in inhibiting the neuronal reuptake of serotonin.

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