Spectrophotometric determination of penicilloates in penicillins
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 114 (9) , 1137-1139
- https://doi.org/10.1039/an9891401137
Abstract
A procedure has been developed for the determination of penicilloates based on the reduction of CuII and detection of CuI using neocuproine. The sensitivity range is 5.6–56 µM penicilloate and the standard deviation was found to be between 1 and 2%. All the penicilloates tested reduced CuII under the conditions of the assay and a slight modification allowed a reasonably accurate determination of the level of this biologically inactive ingredient in a mixture with the parent penicillin. The deterioration of solutions of benzylpenicillin was also studied.Keywords
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