Cytologic Uniformity of Breast Cancer from Different Localizations: A Pattern Analysis Study

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Abstract
Using cytologic pattern analysis it is shown that regions of different histologic structure in one breast cancer are of cytologic homogeneity. The so-called PFORM -the quotient of the total outline length of DNA-particles to the nuclear area – gives an objective cytologic parameter which is independent of DNA content of cancer cells. This objective parameter together with the subjective cytologic parameters described earlier may be a better basis for describing the biologic behavior of breast cancer than histologic structure which is inhomogeneous very often in a lump.