Selection of a Variant Lymphoma Cell Deficient in Adenylate Cyclase
- 28 February 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 187 (4178) , 750-752
- https://doi.org/10.1126/science.163487
Abstract
Isoproterenol, a stimulator of adenylate cyclase, was used to select a stable variant clone of mouse lymphosarcoma cells deficient in the enzyme. The inability of four different stimulators to activate cyclic adenosine monophosphate synthesis in the variant, in contrast to its wild-type parent, implies that in normal cells one type of adenylate cyclase molecular can respond to different activators.Keywords
This publication has 12 references indexed in Scilit:
- Somatic genetic analysis of cyclic AMP action: Characterization of unresponsive mutantsJournal of Cellular Physiology, 1975
- Somatic genetic analysis of cyclic AMP action: Selection of unresponsive mutantsJournal of Cellular Physiology, 1975
- Regulation of Phosphodiesterase Synthesis: Requirement for Cyclic Adenosine Monophosphate-Dependent Protein KinaseScience, 1973
- Cholera toxin-fat cell interaction and the mechanism of activation of the lipolytic responseBiochemistry, 1973
- Gangliosides and membrane receptors for cholera toxinBiochemistry, 1973
- Interaction of Vibrio cholerae enterotoxin with cell membranesBiochemistry, 1973
- Cloning of mouse myeloma cells and detection of rare variantsJournal of Cellular Physiology, 1972
- Cyclic Adenosine Monophosphate in BacteriaScience, 1970
- Production of Highly Purified Choleragen and CholeragenoidThe Journal of Infectious Diseases, 1970
- Pleiotropic deficiency of carbohydrate utilization in an adenyl cyclase deficient mutant of Escherichia coliBiochemical and Biophysical Research Communications, 1969