A Variant of Chronic Granulomatous Disease: Deficient Oxidative Metabolism Due to a Low-Affinity NADPH Oxidase

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Abstract
OUR defense against bacterial infections depends in part on the action of phagocytic leukocytes, which encounter and kill potentially pathogenic microorganisms. A severe reduction in the number or function of phagocytic leukocytes may predispose a person to peculiar, recurrent, or unusually severe infections. One of the first examples of such an impairment discovered was a genetic disorder called chronic granulomatous disease (CGD).1 Phagocytic leukocytes from patients with CGD have an impaired ability to kill certain microorganisms, because the phagocytes cannot produce metabolites of oxygen that are toxic to these microbes.2 , 3 It is believed that an appropriate perturbation of the phagocyte's . . .