CROSS-RESISTANCE TO CARDIOTOXIC AGENTS

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Abstract
Experiments on rats indicate that, following pretreatment with fluorocortisol and Na-acetate, various stressors (restraint, muscular exercise, cold baths, noradrenaline) produce extensive cardiac necroses and high mortality. Gradual adaptation by pretreatment with restraint, muscular exercise, cold baths, or noradrenaline protects against this cardiac-necrosis-eliciting effect of subsequent restraint. This is considered to be an additional example of "cross-resistance" to a stress-induced lesion and illustrates the nonspecificity of the stress mechanism.In similarly conditioned rats, gavage with oil likewise elicits cardiac necroses, but this effect appears to be due to some specific metabolic action, because as used here, the oil elicits no obvious manifestations of stress, and pretreatment with oil protects only against the cardiac-necrosis-eliciting effect of oil itself and not against that of various stressors.

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