Effect of vasoactive peptides on prostacyclin synthesis in man

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Abstract
1 Bradykinin, angiotensin II, arginine vasopressin (AVP) or des-amino-D-arginine vasopressin (DDAVP) were administered by intravenous infusion to 10 healthy men. 2 The concentration of 6-oxo-prostaglandin F1α (6-oxo-PGF1α), the stable hydrolysis product of prostacyclin (PGI2), was measured in plasma using gas chromatography/negative ion chemical ionisation mass spectrometry. 3 Dose-related increases in plasma concentrations of 6-oxo-PGF1α occurred during administration of bradykinin (100–3200 ng kg−1 min−1). The concentrations of 6-oxo-PGF1α rose from baseline values in the range < 1.0–4.9 pg ml−1 to 24.9–47.6 pg ml−1 at maximum tolerated infusion rates. 4 There were no changes in the concentrations of 6-oxo-PGF1α during administration of angiotensin II, AVP or DDAVP at infusion rates which caused haemodynamic changes.