Glucocorticoid receptors, clinical characteristics, and implications for prognosis in chronic lymphocytic leukemia

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Abstract
The cytoplasmic glucocorticoid‐receptor (GR) content was analyzed in peripheral leukocytes from 52 nonselected patients with chronic lymphocytic leukemia (CLL). Forty‐six patients had measurable GR levels. Six patients lacking measurable GR and seven of eight patients with a low GR content had inactive disease. However, there was no significant difference in average GR content between patients with progressive or nonprogressive disease. Twelve GR‐positive patients were treated with prednisolone as the sole medication. Seven patients responded, some in several treatment sessions. There was no correlation between GR‐content and clinical response. Thus, in our experience, cytoplasmic GR measurement has only limited predictive value.