NON-DIFFERENTIATED OLIGOPHRENIAS LINKED WITH X-CHROMOSOME

  • 1 January 1977
    • journal article
    • research article
    • Vol. 13  (7) , 1305-1309
Abstract
In the course of investigation of 262 families with non-differentiated forms of oligophrenias it is established that in 48 families (18.3%) mental deficiency in sibs is caused by pathological mutations in the X-chromosome. In certain inbred families oligophrenia in female persons is also due to mutations linked with X-chromosome. This is supported by the dependence established between the frequency of the cases of oligophrenia among female persons and the inbreeding coefficient for the X-linked loci. The possibility of manifestation of the recessive genes of oligophrenia linked with X-chromosome in heterozygous state is discussed.

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