Possible Hepatotoxicity of Doxidan®

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Abstract
A patient with chronic constipation developed liver injury and leukopenia following the ingestion of Doxidan, a combination drug consisting of danthron and dioctyl calcium sulfosuccinate. Evidence is presented that dioctyl calcium sulfosuccinate may have potentiated the toxicity. The liver injury was associated with deposition of immunoglobulin E in the Kupffer cells. The mechanism of toxicity remains unclear.

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