X-ray studies of enzymes that interact with penicillins
- 1 April 1998
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 54 (4) , 353-358
- https://doi.org/10.1007/s000180050163
Abstract
The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and β-lactamases. An insight into the structural basis for antibiotic resistance is given.Keywords
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