AH23848, a thromboxane antagonist, suppresses ischaemia and reperfusion‐induced arrhythmias in anaesthetized greyhounds

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Abstract
1 The effects of the thromboxane antagonist AH23848 (1 mg kg−1 i.v.) were examined in anaesthetized greyhounds prepared for occlusion of the left anterior descending coronary artery with subsequent reperfusion after 40 min of myocardial ischaemia. 2 Pretreatment with AH23848 30 min before coronary artery occlusion reduced the number of ischaemia-induced extrasystoles to 339 ± 111 compared with 736 ± 153 in the control group. The incidence of ventricular fibrillation following reperfusion was also markedly reduced; 25% compared with 88% in the controls. 3 Late intervention with AH23848, 25 min after the onset of myocardial ischaemia did not significantly alter the incidence of reperfusion-induced ventricular fibrillation; 70% of the control group died and 60% of those that received AH23848. 4 The ischaemia-induced release of thromboxane A2 and prostacyclin was not altered by pretreatment with AH23848. 5 The results suggest that blockade of thromboxane receptors before myocardial ischaemia is an effective antiarrhythmic strategy in this model.

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