Potential bis-alkylating agents for cancer chemotherapy. Approaches to the synthesis of 2-sulfonyl-1,4-bis(dimethanesulfonoxy)butanes

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Abstract
Three general methods for the synthesis of derivatives of the bis-alkylating agent, myleran [an antileukemia drug] [1,4-bis(methanesulfonoxy)butane (1)], were presented. These derivatives contained a lipophilic group attached to the 2 position of 1 by means of a sulfonyl function. As examples of the scope of the methods, the synthesis of 7 such derivatives was presented. All 7 were inactive against L1210 and P388 leukemia in the mouse.

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