Application of Arene−Ruthenium Chemistry to a Formal Total Synthesis of OF 4949 III
- 1 January 1996
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 61 (19) , 6581-6586
- https://doi.org/10.1021/jo960956l
Abstract
A convergent formal total synthesis of OF 4949 III is described. Arene−ruthenium chemistry was used in the construction of the diaryl ether linkage in high yield, and cycloamidation under high dilution conditions (0.005 M) was achieved using DPPA as coupling reagent. SmI2 was used to reductively remove the 2-iodoethyl ester protecting group in the presence of DMPU or HMPA.Keywords
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