THE INFLUENCE OF TESTOSTERONE PROPIONATE ON PIGMENTATION OF THE MAMMARY NIPPLES IN FEMALE MICE

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Abstract
In recent experiments on the influence of testosterone propionate on tumours induced by carcinogens, a striking pigmentation of the mammary nipples in female mice of several strains was observed. The nipples were easily visible against the brighter background of the abdominal coat, while they were hardly noticeable in the untreated mice of the same strains. In previous experiments [Flaks & Ber, 1938, 1939a, b], in which albino mice were treated with very large doses of testosterone propionate, these changes were not noticed, although the mice were maintained for a period of nearly 12 months. It is known from earlier work that injections of oestrogens in guinea-pigs and humans induced hyperpigmentation of the nipples [Lipschutz & Merino, 1932; Watrin, 1934; Hamilton, 1939; Lisser, 1940; Davis & Boynton, 1941; Byron & Katzen, 1941]. Local application of oestrone and stilboestrol was also shown to cause hyperpigmentation of the nipples in male guinea-pigs

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