THE EVOLUTION OF NODULAR GOITER

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Abstract
SIMPLE goiter occurs sporadically all over the world and in the form of endemic goiter affects millions of people in every continent, as a recent World Health Organization conference1 so clearly showed. Simple goiter almost inevitably progresses to the nodular form, and thus a clear knowledge of how these nodules arise and what changes they may undergo is of importance to the doctor, whether he is working in office, hospital, laboratory or public health department. Nodular goiter may become the seat of hyperthyroidism. When this occurs, Plummer (1, 2) and others have stressed that the clinical picture is different from that seen in the younger patient with the non-nodular gland of Graves' disease. Finally, the quickening of interest in thyroid cancer and its possible association with nodular goiter makes a study of the latter mandatory. This particular investigation started with an attempt to calculate more accurately the amount of irradiation received by the thyroid when radioactive iodine is administered therapeutically. This necessitated taking into account the patchy uptake so often seen in autoradiographs prepared from excised portions of the gland.

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