POLYGLUTAMATE FORMS OF FOLATE IN LIVER OF FOLIC ACID-DEFICIENT RATS
- 1 January 1979
- journal article
- research article
- Vol. 49 (1) , 64-69
Abstract
Because of the role played by pteroylpolyglutamates as acutal folate coenzymes in single C unit metabolism, the effect of folic acid deficiency on the distribution of these compounds in rat liver rat studied. In deficient rats the liver levels of pteroylpolyglutamates and in particular of those containing of higher number of glutamyl residues are decreased compared with monoglutamates. Mono-, di- and tri-glutamate ratio is lower in deficient rats than in control rats. The decreased amount of these coenzymic forms may be considered as the consequence of the severe alterations of process which adds glutamate moieties to monoglutamate forms.This publication has 6 references indexed in Scilit:
- Transport and utilization of methyltetrahydrofolates by Lactobacillus casei.Journal of Biological Chemistry, 1976
- Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties.Journal of Biological Chemistry, 1976
- Effects of Biotin on Folic Acid Metabolism in the RatJournal of Nutrition, 1966
- Naturally occurring folates in the blood and liver of the ratAnalytical Biochemistry, 1965
- Folate Activity in Tissues of Rats on Folate-Free Diets.Experimental Biology and Medicine, 1964
- Studies on the folic acid activity of human serumJournal of Clinical Pathology, 1961