Cholinomimetic Treatment Fails to Improve Memory Disorders

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Abstract
To the Editor: Four patients with disordered memory were given pilocarpine (a cholinergic receptor agonist) during an open therapeutic trial. Patient 1, a 31-year-old man, suffered from a persistent, post-traumatic Korsakoff-type syndrome, with confabulation, apathetic joviality, and striking retrograde and anterograde amnesia. Patient 2, a 44-year-old man, had a persistent anterograde amnesia as a postoperative complication after the removal of a third ventricular colloid cyst. He also had impairment of detailed recall of past experiences, beginning with those of the late 1960's. Patient 3, a 55-year-old woman, was presumptively diagnosed as having Alzheimer-type dementia; though she was independent in daily . . .

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