Isotretinoin Use and Risk of Depression, Psychotic Symptoms, Suicide, and Attempted Suicide
Open Access
- 1 October 2000
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 136 (10) , 1231-1236
- https://doi.org/10.1001/archderm.136.10.1231
Abstract
ISOTRETINOIN (13-cis-retinoic acid) is the active ingredient of Roaccutane or Accutane (F. Hoffmann–La Roche Ltd, Basel, Switzerland), which is indicated for the treatment of severe recalcitrant nodulocystic acne. Isotretinoin is a retinoid, the 13-cis isomer of all-trans-retinoic acid (tretinoin) and a derivative of vitamin A. Acne vulgaris affects approximately 80% to 90% of teenagers but also affects individuals in their 20s and 30s.1Keywords
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