Neuronal expression of a newly identified Drosophila melanogaster G protein alpha 0 subunit.
- 1 November 1989
- journal article
- research article
- Published by American Society for Cell Biology (ASCB) in Cell Regulation
- Vol. 1 (1) , 125-134
- https://doi.org/10.1091/mbc.1.1.125
Abstract
We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.This publication has 33 references indexed in Scilit:
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