ACTION OF TESTOSTERONE ADMINISTERED NEONATALLY ON THE RAT PERINEAL COMPLEX

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Abstract
Wainman & Shipounoff (1941) found a stimulatory effect of testosterone upon the perineal complex. The development of perineal tissues may be altered by neonatal steroid treatment. Seminal vesicles of both rats and mice castrated at birth are more responsive to adult testosterone treatment, if the same hormone has been injected in early life (Tucker, 1964; Bronson, Whitsett, & Hamilton, 1972). The present experiments are concerned with such sensitization of the perineal complex (penis and its bulb and levator ani muscles). The object of this study was to examine the effect of neonatal androgenization on testosterone-induced nucleic acid synthesis in the levator ani muscles and to compare such results with the seminal vesicle, which is a relatively uncontaminated example of biochemical priming (Bronson et al. 1972). Seventy-four male Wistar rats from the randomly mated closed colony maintained in the Anatomy Department were used. Males were castrated on day 2 after birth

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