Irresistible IRES
- 1 October 2001
- journal article
- review article
- Published by Springer Nature in EMBO Reports
- Vol. 2 (10) , 893-898
- https://doi.org/10.1093/embo-reports/kve208
Abstract
Studies on the control of eukaryotic translation initiation by a cap‐independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.Keywords
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