A Morphogenetic Matrix for Differentiation of Cartilage in Tissue Culture

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Abstract
Under the influence of a substratum consisting of cold 0.6 N HCl-decalcified bone matrix, mesenchymal cells of muscle cultured in a series of chemically defined media aggregate and differentiate into chondrocytes which become enclosed in a calcifiable intercellular matrix. For reasons unknown, in nearly every other culture, mesenchymal cells do not gain contact with the bone substratum but grow radially out onto the surface of the plastic container to form monolayers of fibroblasts.

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