Effect of Underfeeding on Thyroxine Secretion Rate of Female Mice.

Publisher Website
Google Scholar
Abstract
Adult female Swiss Webster mice kept at temperature of 78[degree] F ate 1.3 g/10 g body weight/day of Purina Lab. Chow. Their daily L-thyroxine secretion rate (TSR) was 1.38 t .173 /ig/100 g body weight. Mice fed 3/4 ration for 16 days showed TSR of 0.93 fig/100 g/day, a significant reduction of 33%, yet no loss in body weight occurred. On 1/2 ration the TSR was reduced to 0.80 jug/100 g/day or 41% associated with a 17.3% reduction in body weight. These data suggest that pituitary-thyroid axis is sensitive to slight reduced energy intake by reduction in TSR sufficient to maintain body weight.