Implications of New Proteomics Strategies for Biology and Medicine
- 31 January 2004
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 3 (2) , 253-260
- https://doi.org/10.1021/pr034082c
Abstract
Advances in proteomics have fundamentally changed the paradigm of discovery for drug targets and novel biomarkers. Proteomics methodologies currently used will be reviewed in this paper, including structural proteomics, quantitative proteomics, and functional proteomics. A strategy to identify differentially expressed cell surface proteins as monoclonal therapeutic targets in oncology will be discussed. Keywords: structural proteomics • functional proteomics • quantitative proteomics • mass spectrometry • medicine • oncologyKeywords
This publication has 16 references indexed in Scilit:
- Advances in quantitative proteomics using stable isotope tagsTrends in Biotechnology, 2002
- Shotgun identification of protein modifications from protein complexes and lens tissueProceedings of the National Academy of Sciences, 2002
- Epitope mapping of a monoclonal antibody against human thrombin by H/D‐exchange mass spectrometry reveals selection of a diverse sequence in a highly conserved proteinProtein Science, 2002
- Processing Complex Mixtures of Intact Proteins for Direct Analysis by Mass SpectrometryAnalytical Chemistry, 2002
- Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiaeNature Biotechnology, 2002
- Comparative proteomics based on stable isotope labeling and affinity selectionJournal of Mass Spectrometry, 2002
- Functional organization of the yeast proteome by systematic analysis of protein complexesNature, 2002
- Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases.Proceedings of the National Academy of Sciences, 1993
- Some Developments in Nuclear Magnetic Resonance of SolidsScience, 1989
- Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltonsAnalytical Chemistry, 1988