ORAL THERAPY OF ADRENAL CORTICAL HYPOFUNCTION

Publisher Website
Google Scholar
Abstract
The treatment of adrenal cortical hypofunction (Addison's disease) has evolved from the fairly unpredictable precarious control of the patient by the use of oral ingestion of high doses of sodium chloride to a more precise, effective, physiological management based on the use of intramuscular administration of desoxycorticosterone acetate in oil. Pellet implantation of the same steroid soon led to even more exact control of adrenal cortical hypofunction with less frequent administration of the necessary steroid. Infrequent intramuscular therapy has been achieved more recently by administration of aqueous suspensions of other esters of desoxycorticosterone; in particular, the trimethylacetate derivative, which has been used with success, may be administered only once every four weeks in most patients. The use of desoxycorticosterone trimethylacetate, plus supplementary oral therapy with cortisone, until recently, has resulted in optimum therapeutic control of most patients with adrenal cortical hypofunction. The use of oral therapy involving cortisone alone yielded

This publication has 0 references indexed in Scilit: