SELECTIVE-INHIBITION OF PROTEIN SYNTHETIC ACTIVITY OF CEREBRAL MEMBRANE-BOUND RIBOSOMES AS A CONSEQUENCE OF ETHANOL INGESTION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (1) , 185-188
Abstract
Ethanol ingestion by weanling rats results in an inhibition of protein synthetic activity of cerebral membrane-bound ribosomes. Among various amino acids tested, the incorporation of serine was inhibited to a maximum degree. In contrast to membrane-bound ribosomes, the activity of free ribosomes was enhanced as a consequence of ethanol treatment. Aminoacylation of tRNA in pH 5 fraction was also reduced in the brain cortices of ethanol-fed animals.

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