Platelet aggregation potentiators from Cho-Rei.

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Abstract
Four components were isolated from Cho-Rei (Polyporus umbellatus), one of the traditional Chinese medicines, and three of them potentiated the rabbit platelet aggregation response induced by collagen and or adenosine-5''-diphosphate in vitro. The four components were identified as ergosta-7,22-dien-3-one, ergosta-7,22-dien-3-ol, 5.alpha.,8.alpha.-epidioxyergosta-6,22-dien-3-ol and the already known component, ergosterol. When the C3-hydroxy group of the active components was replaced by a ketone group, the enhancing activity disappeared, and an inhibitory tendency was observed. This suggests a relationship between bioactivity and the C3-hydroxy group (or polarity) of these components.