Responses of arterial smooth muscle from normotensive and pre-eclamptic subjects to the calcium channel agonist, Bay K 8644
- 1 November 1987
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Die Gesamte Experimentelle Medizin
- Vol. 187 (6) , 461-468
- https://doi.org/10.1007/bf01852184
Abstract
The effect of Bay K 8644, a dihydropyridine Ca2+ agonist, on in vitro contractile responses of inferior epigastric arteries from normotensive (N) and pre-eclamptic (P) subjects has been investigated, with a view to further defining the mechanism of the increased vascular sensitivity associated with pregnancy-induced hypertension. Bay K 8644 (10−10−10−7M) caused dose-dependent contractions of N as well as P arteries under resting conditions in the order: P > N and caused development of rhythmic contractions in both N and P arteries. Bay K 8644 effects were prevented by 3 × 10−8M Nifedipine (a Ca+2 antagonist). Bay K 8644 also significantly (P < 0.05) enhanced the sensitivity as well as maximal contractile responses to CaCl2 in 40 mM K+-depolarized Ca-depleted N and P arteries in the order: P > N. The results suggest that the increased peripheral vascular sensitivity associated with pregnancy-induced hypertension may be due, at least in part, to enhanced activity of the potential-sensitive Ca2+ channels in arterial smooth muscle plasmalemma.Keywords
This publication has 17 references indexed in Scilit:
- Calcium and muscle contractionPublished by Elsevier ,2003
- Role of endothelium in magnesium-induced relaxation of rat aortaZeitschrift für Die Gesamte Experimentelle Medizin, 1987
- Abnormal vascular function and morphology in preeclampsia: a study of isolated resistance vesselsClinical Science, 1985
- Mechanism of hydralazine-induced relaxation of arterial smooth muscleCardiovascular Research, 1985
- Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonistsNature, 1984
- Preeclampsia -- a state of prostaglandin deficiency? Urinary prostaglandin excretion, the renin-aldosterone system, and circulating catecholamines in preeclampsia.Hypertension, 1983
- Mechanisms of action of transmitters and other substances on smooth muscle.Physiological Reviews, 1979
- A Study of Angiotensin II Pressor Response throughout Primigravid PregnancyJournal of Clinical Investigation, 1973
- Vascular Smooth Muscle UpdatedCirculation Research, 1973
- Renin-angiotensin system in normal and toxemic pregnanciesAmerican Journal of Obstetrics and Gynecology, 1968