Significance of ratios of different volumes of distribution in pharmacokinetics
Open Access
- 1 July 1983
- journal article
- review article
- Published by Wiley in Biopharmaceutics & Drug Disposition
- Vol. 4 (3) , 263-270
- https://doi.org/10.1002/bdd.2510040307
Abstract
Multicompartmental pharmacokinetics involves the four volumes: Vc = volume of the central compartment; Vss = volume of distribution steady-state; Vβ = volume of distribution beta; and Vext = the extrapolated volume of distribution. The ratio Vc/Vext is indicative of the degree of multicompartmental character of a set of data. The quantity (Vext/Vβ)−1 is the fractional error in the total clearance when one assumes a monoexponential rather than a polyexponential equation for disposition of a drug. The ratio Vss/Vβ indicates how well the one-compartment body model predicts average amounts of drug in the body when a multicompartmental model is actually operative. The quantity (Vss/Vc)− 1 is equal to either k12/k21 or k12/k21 + k13/k31 of the two- and three-compartmental mammillary models. Examples from the literature are reported and discussed.Keywords
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