Syngeneic tumor cells can induce alloreactive T killer cells: a biological role for transplantation antigens.

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Abstract
A chemically [methylcholanthrene] induced sarcoma of BALB/c (H-2d) mice, MCG4 cells, induced in BALB/c lymphocytes a primary anti-tumor cytolytic T lymphocyte (CTL) reaction in vitro. The anti-tumor CTL showed tumor specificity, but reacted also with normal cells expressing distinct H-2 alloantigens. The CTL response was induced by and directed against alloantigenic determinants expressed on 2 different molecules, one H-2Kk-like the other H-2Dk-like. The biological significance of these findings is discussed with regard to the following: possibility of derepression of normally silent H-2 genes in tumor cells and normal cells, generation of alloreactivity in ontogeny, and role of alloreactive T cells in eliminating cells expressing wrong H-2 antigens.