Human CSF-1: gene structure and alternative splicing of mRNA precursors.

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Abstract
Bone marrow progenitor cells differentiate into mononuclear phagocytes in the presence of colony stimulating factor‐1 (CSF‐1). Characterization of the human CSF‐1 gene shows that it contains 10 exons and 9 introns, which span 20 kb. Analysis of multiple CSF‐1 transcripts demonstrates that alternate use of exon 6 splice acceptor sites and 3′ noncoding sequence exons occurs. These alternatively spliced transcripts can encode either a 224 or a 522 amino acid CSF‐1. Implications of differential splicing for the production and function of CSF‐1 are discussed.