Surface Tensions of Proteins in Aqueous Solutions

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Abstract
Changes in conformation of proteins in solution may be detected by determin ing the relative surface tensions of their solutions. Of the proteins examined, all of the enzymes had distinct changes in surface tensions upon going from a 3M NaCl medium to a salt-free aqueous solution. Only two of the seven non- enzymic proteins underwent detectable changes in the same cycle. These relative surface tensions could be of value in determining adsorption/elution profiles for hydrophobic interaction chromatography.