Evolution of C2H2-zinc finger genes and subfamilies in mammals: Species-specific duplication and loss of clusters, genes and effector domains
Open Access
- 18 June 2008
- journal article
- research article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 8 (1) , 176
- https://doi.org/10.1186/1471-2148-8-176
Abstract
C2H2 zinc finger genes (C2H2-ZNF) constitute the largest class of transcription factors in humans and one of the largest gene families in mammals. Often arranged in clusters in the genome, these genes are thought to have undergone a massive expansion in vertebrates, primarily by tandem duplication. However, this view is based on limited datasets restricted to a single chromosome or a specific subset of genes belonging to the large KRAB domain-containing C2H2-ZNF subfamily.Keywords
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