Comment on "Evidence for Positive Epistasis in HIV-1"
- 12 May 2006
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 312 (5775) , 848
- https://doi.org/10.1126/science.1109904
Abstract
Bonhoeffer et al . (Reports, 26 November 2004, p. 1547) presented evidence for positive epistasis in a clinical data set of HIV-1 mutants and corresponding fitness values. We demonstrate that biases in the original and simulated data sets may lead to erroneous evidence for epistasis. More rigorous statistical tests must be used to account for such biases before one can infer epistasis.Keywords
This publication has 6 references indexed in Scilit:
- Phenotypic Hypersusceptibility to Multiple Protease Inhibitors and Low Replicative Capacity in Patients Who Are Chronically Infected with Human Immunodeficiency Virus Type 1Journal of Virology, 2005
- Evidence for Positive Epistasis in HIV-1Science, 2004
- Genetic Basis of Hypersusceptibility to Protease Inhibitors and Low Replicative Capacity of Human Immunodeficiency Virus Type 1 Strains in Primary InfectionJournal of Virology, 2004
- Implications of antiretroviral resistance on viral fitnessCurrent Opinion in Infectious Diseases, 2001
- Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapyAIDS, 1999
- Selection against harmful mutations in large sexual and asexual populationsGenetics Research, 1982