IMMUNIZATION EXPERIMENTS WITH SWINE INFLUENZA VIRUS

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Abstract
Expts. were conducted to determine the effect of dosage, route of administration and animal source upon the efficacy of swine influenza virus in immunizing swine, ferrets and mice against infection following intranasal instillation of the virus. Swine were protected by subcut. or intramuscular injection of either homologus virus (virus derived from swine) or heterol-ogous (virus derived from ferrets or mice). Both ferrets and mice were protected by subcut. injection of homologous but not heterologous virus. Repeated injections were more effective than a single one. Intra-peritoneal inoculation of both mice and ferrets with swine influenza virus protected against intranasal infection, whether the virus used as vaccine was obtained from the lungs of infected mice, ferrets, or swine. Exceptional instances are cited of two droves of swine in which swine influenza followed the intramuscular injection of virus.

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