Relative bioavailability of a paracetamol suppository
- 1 January 1980
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 17 (6) , 465-468
- https://doi.org/10.1007/bf00570165
Abstract
Summary The relative bioavailability of a new paracetamol suppository (Panodil) and tablets in doses of 0.5 and 1 g was investigated in eight healthy subjects. The tablets were absorbed faster and higher peak plasma concentrations were obtained than after the suppositories. The bioavailability of the suppositories was approximately 80% of that of the tablets at both dose levels. There was no indication of capacity-limited elimination at either the two doses investigated.Keywords
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