Choline and the “cholesterol” fatty liver

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Abstract
Large nos. of rats were fed on a diet containing fat and 2% cholesterol, to produce "cholesterol" fatty livers. In the "cholesterol" fatty liver so produced the amts. of cholesteryl ester and glyceride were markedly increased, agreeing to this extent with the observations of other workers, but not in the degree of increase. Further groups of animals after receiving this preparatory diet were transferred to various diets with and without added choline. Analysis at successive periods up to 12 days of pooled samples of the livers of different groups receiving diets with and without added choline indicated that choline has no obvious effect in decreasing any of the lipid constituents save perhaps the glyceride fraction. Such pos. evidence as these results may afford seems to confirm the view previously expressed by Best, Channon and Ridout that the effect of choline is on the glyceride fraction and that its action in preventing the deposition of cholesteryl esters is secondary to this effect on the neutral fat.

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