CEA-LIKE ANTIGENS IN DIFFERENT HISTOLOGIC TYPES OF HUMAN-LUNG CARCINOMA

  • 1 January 1979
    • journal article
    • research article
    • Vol. 26  (2) , 145-156
Abstract
Comparative studies on the presence and immunological reactivity of CEA [carcinoembryonic antigen] and CEA-like antigens in lung and digestive tract cancers were performed. Specific goat and rabbit anti-CEA immune sera were used. Immunofluorescence studies revealed in histologically different types of the lung carcinomas the presence of the cross reacting antigen with classical CEA. Absorption procedures and double diffusion tests showed the existence of at least 2 antigenic determinants in the CEA molecule: the determinant specific for the lower parts of the digestive tract cancers not found in the lung carcinomas, and the determinant common for the lung and the digestive tract cancers.

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